New research has revealed a role for splicing proteins in the pathology of Alzheimer's disease. Increased phosphorylation of the SRRM2 protein, seen in AD mouse models and human patients, was found to block its transport to the nucleus. This reduced levels of the PQBP1 protein, causing abnormal changes to the splicing of synapse genes and cognitive decline. These phenotypes were reversed by restoring PQBP1 function, suggesting a possible future treatment for AD.
Early changes to synapse gene regulation may cause Alzheimer's
New research has revealed a role for splicing proteins in the pathology of Alzheimer's disease. Increased phosphorylation of the SRRM2 protein, seen in AD mouse models and human patients, was found to block its transport to the nucleus. This reduced levels of the PQBP1 protein, causing abnormal changes to the splicing of synapse genes and cognitive decline. These phenotypes were reversed by restoring PQBP1 function, suggesting a possible future treatment for AD.
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dazed yet not confuzzled
My LJ is etreeemly slow, right now. So, I'm not going to be around until that changes. I just wanted to mention: Do you know what is a really…
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LiveJournal is 22 today!
Domain LiveJournal.com was registered on April 15, 1999. The same year, the cult movie "The Matrix" was released, the 6 billionth inhabitant of the…
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DNC Dems have to devolve EVERYTHING into RACISM.
So, I made my way to the library yesterday, despite a little CFS. Mainly worked on bank stuff while burning CDs. My request for, "Slacker,"…
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